Intrathecal Injection of the Secretome from ALS Motor Neurons Regulated for miR-124 Expression Prevents Disease Outcomes in SOD1-G93A Mice

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with short life expectancy and no effective therapy.We previously identified upregulated miR-124 in NSC-34-motor neurons (MNs) expressing human SOD1-G93A (mSOD1) and established its implication in mSOD1 MN degeneration and glial cell activation.When anti-miR-124-treated mSOD1 MN (pr

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Development and Application of Reverse Lancing Equipment for the Secondary Side of Steam Generator in Nuclear Power Plants

It is absolutely necessary to expand high pressure lancing area in order to ensure the operation safety of steam generator transfer heat tubes in nuclear power plants.Considering the structure at the secondary Toners side of the steam generator, and in compliance with the guidelines of reducing cost and increasing the compatibility, the reverse lan

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Personality factors and pandemic-related behaviors

PurposeThe purpose of the current study was to determine whether there are personality differences (the HEXACO Swim Shirts model, narcissism, sadism, compassion for others) in mask-wearing, social distancing, and hoarding.FindingsThose who always wore masks were significantly higher in compassion for others and significantly lower in sadism compare

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Gauge-fixing local H symmetry in supergravities

Abstract We discuss known maximal D-dimensional supergravities of two types: type I with G/H coset spaces and type II derived by compactification from higher dimensions without dualization, these have less manifest symmetries.In 4D and 6D in type I models we perform explicit gauge-fixing of local H symmetries in unitary Swim Shirts gauges: symmetri

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